منابع مشابه
Isolating SRP
Isolating SRP ike a crate of beer ready to be shipped overseas, secretory proteins carry a label that says, “For Export.” With clever experiments, Günter Blobel of Rockefeller University and his post-doc Bernhard Dobberstein (Blobel and Dobberstein, 1975a,b) showed that the cell’s export label is the signal sequence, a short stretch of amino acids that guides the forming protein to the ER (see ...
متن کاملA distinct mechanism to achieve efficient signal recognition particle (SRP)-SRP receptor interaction by the chloroplast srp pathway.
Cotranslational protein targeting by the signal recognition particle (SRP) requires the SRP RNA, which accelerates the interaction between the SRP and SRP receptor 200-fold. This otherwise universally conserved SRP RNA is missing in the chloroplast SRP (cpSRP) pathway. Instead, the cpSRP and cpSRP receptor (cpFtsY) by themselves can interact 200-fold faster than their bacterial homologues. Here...
متن کاملThe signal recognition particle (SRP) RNA links conformational changes in the SRP to protein targeting.
The RNA component of the signal recognition particle (SRP) is universally required for cotranslational protein targeting. Biochemical studies have shown that SRP RNA participates in the central step of protein targeting by catalyzing the interaction of the SRP with the SRP receptor (SR). SRP RNA also accelerates GTP hydrolysis in the SRP.SR complex once formed. Using a reverse-genetic and bioch...
متن کاملComparison between scaling-root-planing (SRP) and SRP/photodynamic therapy: six-month study
INTRODUCTION The purpose of this long-term clinical study was to examine the additional efficacy of photodynamic therapy (PDT) to scaling and root planing (SRP) in patients with chronic periodontal disease. METHODS A total of 22 patients (mean age: 59.3 ± 11.7 years) with chronic periodontal disease and four teeth with probing depth ≥ 5 mm were enrolled in the study. Inclusion criteria were: ...
متن کاملSignal recognition particle (SRP) and SRP receptor: a new paradigm for multistate regulatory GTPases.
The GTP-binding proteins or GTPases comprise a superfamily of proteins that provide molecular switches in numerous cellular processes. The "GTPase switch" paradigm, in which a GTPase acts as a bimodal switch that is turned "on" and "off" by external regulatory factors, has been used to interpret the regulatory mechanism of many GTPases for more than two decades. Nevertheless, recent work has un...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2005
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1711fta2